Apoquel vs Cyclosporine: what's the difference?
How Apoquel and Cyclosporine compare: what each is for, how it works, side effects and cost, side by side.
Last updated: October 2026 · 3 sources · see sources
Side by side
| Apoquel | Cyclosporine | |
|---|---|---|
| Generic name | Oclacitinib | Cyclosporine (oral) |
| Brand names | Apoquel | Atopica, Atopica for Cats |
| For | Dogs | Dogs and cats |
| Prescription | Prescription | Prescription |
| Used for | Controls itching from allergic skin disease, including atopic dermatitis, in dogs at least 12 months old. Vets occasionally use it for other skin problems. [1] | Treats atopic dermatitis (skin allergies) in dogs and cats, plus other immune-related conditions. [2] |
| How it works | It blocks JAK enzymes, which are part of the signal chain that drives itch and inflammation. Many dogs feel relief within a day or two. [1] | It adjusts the immune cells involved in an allergic reaction, which lowers itch and inflammation. It can take a few weeks to reach full effect. [2] |
| Common side effects | Vomiting, diarrhea or a lower appetite; tiredness; a higher chance of infections such as urinary, skin or respiratory infections; new skin lumps. [1] | Vomiting, diarrhea and lower appetite are the most common. Rarely, more infections or cancers. [2] |
| Use with care | Not for dogs with recent or current demodectic mange, serious infections, or cancer. Wear gloves or wash your hands after handling. Call your vet about fever, breathing trouble or any new lump. [1] | Not for pets with a history of cancer, pets that are breeding, pregnant or nursing, or pets under six months old. Your vet may want bloodwork during long-term use. [2] |
| Typical price | Apoquel pills, per fill: $30–$90 [3] | No reliable published price |
| Full guide | Apoquel guide | Cyclosporine (Atopica) guide |
Key differences
- They aren't made for the same animals: Apoquel is for dogs; Cyclosporine is for dogs and cats.
Which one is right for my pet?
That is a call for your vet. They weigh your pet's age, weight, other health problems, other medicines and what you can realistically give at home.
Switching from Apoquel to Cyclosporine is common, but do it only with your vet's plan.
Common questions
What is the difference between Apoquel and Cyclosporine?
Both treat allergic skin disease. Apoquel often works within a day or two; cyclosporine (Atopica) can take a few weeks to reach full effect and is also used in cats.
Is Apoquel better than Cyclosporine?
Neither is better for every pet. Your vet chooses based on your pet's species, age, health history, other medicines and what you can manage at home.
Can my pet take Apoquel and Cyclosporine together?
Only if your vet says so. Some medicines in the same family should not be combined, and others are often used together. Always check before adding or switching.
Do Apoquel and Cyclosporine need a prescription?
Apoquel: Yes. It needs a prescription from a veterinarian. Cyclosporine: Yes. It needs a prescription from a veterinarian.
How much do Apoquel and Cyclosporine cost?
Apoquel: Apoquel pills, per fill $30–$90. Cyclosporine: no reliable published price. Prices vary by pet size, pharmacy and clinic.
Related
This page is general information for planning, not veterinary advice. Talk to your vet about your own pet.