Apoquel vs Cytopoint: what's the difference?
How Apoquel and Cytopoint compare: what each is for, how it works, side effects and cost, side by side.
Last updated: October 2026 · 3 sources · see sources
Side by side
| Apoquel | Cytopoint | |
|---|---|---|
| Generic name | Oclacitinib | Lokivetmab |
| Brand names | Apoquel | Cytopoint |
| For | Dogs | Dogs |
| Prescription | Prescription | Prescription, given at the clinic |
| Used for | Controls itching from allergic skin disease, including atopic dermatitis, in dogs at least 12 months old. Vets occasionally use it for other skin problems. [1] | Treats itching and skin inflammation in dogs, usually from skin allergies. [2] |
| How it works | It blocks JAK enzymes, which are part of the signal chain that drives itch and inflammation. Many dogs feel relief within a day or two. [1] | It is an antibody injection that soaks up one of the proteins that sends the itch signal. One shot usually lasts several weeks. [2] |
| Common side effects | Vomiting, diarrhea or a lower appetite; tiredness; a higher chance of infections such as urinary, skin or respiratory infections; new skin lumps. [1] | Sleepiness, vomiting, diarrhea, low appetite and soreness at the injection spot. Skin redness and ear infections were seen occasionally in safety studies. [2] |
| Use with care | Not for dogs with recent or current demodectic mange, serious infections, or cancer. Wear gloves or wash your hands after handling. Call your vet about fever, breathing trouble or any new lump. [1] | Dogs only. If given with vaccines, it should go in a different spot on the body. Watch for signs of an allergic reaction such as facial swelling or hives. [2] |
| Typical price | Apoquel pills, per fill: $30–$90 [3] | Cytopoint shot, given at the vet every 4 to 8 weeks: $50–$150 [3] |
| Full guide | Apoquel guide | Cytopoint guide |
Key differences
- How you get them differs: Apoquel is prescription; Cytopoint is prescription, given at the clinic.
- A clinic-given medicine means a trip to the vet each time, which adds visit fees but takes the daily pill off your plate.
Which one is right for my pet?
That is a call for your vet. They weigh your pet's age, weight, other health problems, other medicines and what you can realistically give at home.
Switching from Apoquel to Cytopoint is common, but do it only with your vet's plan.
Common questions
What is the difference between Apoquel and Cytopoint?
Both calm allergy itch in dogs. Apoquel is a pill given at home that blocks JAK enzymes; Cytopoint is an antibody shot given at the clinic that usually lasts several weeks.
Is Apoquel better than Cytopoint?
Neither is better for every pet. Your vet chooses based on your pet's species, age, health history, other medicines and what you can manage at home.
Can my pet take Apoquel and Cytopoint together?
Only if your vet says so. Some medicines in the same family should not be combined, and others are often used together. Always check before adding or switching.
Do Apoquel and Cytopoint need a prescription?
Apoquel: Yes. It needs a prescription from a veterinarian. Cytopoint: Yes. It's prescription-only and is usually given at the vet clinic.
How much do Apoquel and Cytopoint cost?
Apoquel: Apoquel pills, per fill $30–$90. Cytopoint: Cytopoint shot, given at the vet every 4 to 8 weeks $50–$150. Prices vary by pet size, pharmacy and clinic.
Related
This page is general information for planning, not veterinary advice. Talk to your vet about your own pet.