Bravecto vs Simparica: what's the difference?
How Bravecto and Simparica compare: what each is for, how it works, side effects and cost, side by side.
Last updated: October 2026 · 2 sources · see sources
Side by side
| Bravecto | Simparica | |
|---|---|---|
| Generic name | Fluralaner | Sarolaner |
| Brand names | Bravecto, Bravecto Plus | Simparica, Simparica Trio, Revolution Plus |
| For | Dogs and cats | Dogs and cats |
| Prescription | Prescription | Prescription |
| Used for | Kills fleas and ticks for up to 12 weeks in dogs and cats. Sometimes used for mange and ear mites. [1] | Kills fleas and ticks in dogs. Combined products also cover heartworm and worms, and Revolution Plus is made for cats. [2] |
| How it works | After it is given, it spreads through the body. Fleas and ticks are exposed when they bite and are killed. [1] | Absorbed into the body; fleas and ticks are killed when they feed. [2] |
| Common side effects | Vomiting, diarrhea, low appetite and flaky skin. [1] | Vomiting, diarrhea and low appetite. [2] |
| Use with care | It belongs to the isoxazoline class, which the FDA says has been linked to tremors, wobbliness and seizures in some pets. Tell your vet if your pet has ever had a seizure. [1] | The single-drug Simparica chew is not for cats. An isoxazoline, so use caution in pets with seizures. [2] |
| Full guide | Bravecto guide | Simparica guide |
Key differences
On the basics they are alike: same kind of animal, same way to get them. The differences are in how they work and what else they cover, shown in the table above.
Which one is right for my pet?
That is a call for your vet. They weigh your pet's age, weight, other health problems, other medicines and what you can realistically give at home.
Switching from Bravecto to Simparica is common, but do it only with your vet's plan.
Common questions
What is the difference between Bravecto and Simparica?
Both kill fleas and ticks from inside the body. Bravecto lasts up to 12 weeks; Simparica's combination products add heartworm and worm protection.
Is Bravecto better than Simparica?
Neither is better for every pet. Your vet chooses based on your pet's species, age, health history, other medicines and what you can manage at home.
Can my pet take Bravecto and Simparica together?
Only if your vet says so. Some medicines in the same family should not be combined, and others are often used together. Always check before adding or switching.
Do Bravecto and Simparica need a prescription?
Bravecto: Yes. It needs a prescription from a veterinarian. Simparica: Yes. It needs a prescription from a veterinarian.
Related
This page is general information for planning, not veterinary advice. Talk to your vet about your own pet.