Cytopoint vs Zenrelia: what's the difference?
How Cytopoint and Zenrelia compare: what each is for, how it works, side effects and cost, side by side.
Last updated: October 2026 · 3 sources · see sources
Side by side
| Cytopoint | Zenrelia | |
|---|---|---|
| Generic name | Lokivetmab | Ilunocitinib |
| Brand names | Cytopoint | Zenrelia |
| For | Dogs | Dogs |
| Prescription | Prescription, given at the clinic | Prescription |
| Used for | Treats itching and skin inflammation in dogs, usually from skin allergies. [1] | Controls itching from allergic and atopic dermatitis in dogs at least 12 months old. [2] |
| How it works | It is an antibody injection that soaks up one of the proteins that sends the itch signal. One shot usually lasts several weeks. [1] | Like Apoquel, it is a JAK inhibitor that quiets the immune signals behind itch and inflammation. [2] |
| Common side effects | Sleepiness, vomiting, diarrhea, low appetite and soreness at the injection spot. Skin redness and ear infections were seen occasionally in safety studies. [1] | Low appetite or energy, vomiting or diarrhea, ear infections and other infections. [2] |
| Use with care | Dogs only. If given with vaccines, it should go in a different spot on the body. Watch for signs of an allergic reaction such as facial swelling or hives. [1] | Dogs must be up to date on vaccines, and it should not be started within 28 days of a vaccine. Not for pregnant or nursing dogs. Ask your vet how it fits with your dog's vaccine schedule. [2] |
| Typical price | Cytopoint shot, given at the vet every 4 to 8 weeks: $50–$150 [3] | No reliable published price |
| Full guide | Cytopoint guide | Zenrelia guide |
Key differences
- How you get them differs: Cytopoint is prescription, given at the clinic; Zenrelia is prescription.
- A clinic-given medicine means a trip to the vet each time, which adds visit fees but takes the daily pill off your plate.
Which one is right for my pet?
That is a call for your vet. They weigh your pet's age, weight, other health problems, other medicines and what you can realistically give at home.
Switching from Cytopoint to Zenrelia is common, but do it only with your vet's plan.
Common questions
What is the difference between Cytopoint and Zenrelia?
Both treat allergy itch in dogs. Cytopoint is a shot at the clinic that lasts several weeks; Zenrelia is a JAK-inhibitor pill given at home.
Is Cytopoint better than Zenrelia?
Neither is better for every pet. Your vet chooses based on your pet's species, age, health history, other medicines and what you can manage at home.
Can my pet take Cytopoint and Zenrelia together?
Only if your vet says so. Some medicines in the same family should not be combined, and others are often used together. Always check before adding or switching.
Do Cytopoint and Zenrelia need a prescription?
Cytopoint: Yes. It's prescription-only and is usually given at the vet clinic. Zenrelia: Yes. It needs a prescription from a veterinarian.
How much do Cytopoint and Zenrelia cost?
Cytopoint: Cytopoint shot, given at the vet every 4 to 8 weeks $50–$150. Zenrelia: no reliable published price. Prices vary by pet size, pharmacy and clinic.
Related
This page is general information for planning, not veterinary advice. Talk to your vet about your own pet.