Pain & arthritis Dogs & Cats

Amantadine for dogs and cats

Used mainly as an add-on for long-term pain, often with an NSAID, opioid or gabapentin. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerAmantadine is a prescription medicine for dogs and cats. Originally an antiviral, it also blocks NMDA receptors that keep pain signals 'turned up' in chronic pain. The most common side effects: not well studied in pets.

Key facts

Generic nameAmantadine
Common brand namesSymmetrel
Used inDogs & Cats
TypePain & arthritis
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

Used mainly as an add-on for long-term pain, often with an NSAID, opioid or gabapentin. [1]

How it works

Originally an antiviral, it also blocks NMDA receptors that keep pain signals 'turned up' in chronic pain. [1]

Side effects and cautions

Common side effects: Not well studied in pets. Possible agitation, soft stool, diarrhea and gas. [1]

Use with care: Avoid in pets with untreated glaucoma. Use caution with liver, kidney or heart disease or seizures. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Amantadine FAQ

What is Amantadine used for in dogs and cats?

Used mainly as an add-on for long-term pain, often with an NSAID, opioid or gabapentin.

What are the side effects of Amantadine?

Not well studied in pets. Possible agitation, soft stool, diarrhea and gas.

Does Amantadine need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Amantadine should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

Related medications

Related cost guides

This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Amantadine (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs