Antifungals Dogs & Cats

Fluconazole for dogs and cats

Treats fungal infections, especially those that reach the brain or spinal cord. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerFluconazole is a prescription medicine for dogs and cats. It disrupts the membrane fungi need to survive. The most common side effects: low appetite, vomiting, diarrhea and, with long-term use, liver injury.

Key facts

Generic nameFluconazole
Common brand namesDiflucan
Used inDogs & Cats
TypeAntifungals
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

Treats fungal infections, especially those that reach the brain or spinal cord. [1]

How it works

It disrupts the membrane fungi need to survive. [1]

Side effects and cautions

Common side effects: Low appetite, vomiting, diarrhea and, with long-term use, liver injury. [1]

Use with care: Use caution in pets with liver or kidney disease. Your vet may check bloodwork during long courses. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Fluconazole FAQ

What is Fluconazole used for in dogs and cats?

Treats fungal infections, especially those that reach the brain or spinal cord.

What are the side effects of Fluconazole?

Low appetite, vomiting, diarrhea and, with long-term use, liver injury.

Does Fluconazole need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Fluconazole should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

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This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Fluconazole (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs