Urinary & kidney Dogs

Proin for dogs

Treats urinary incontinence from a weak urethral sphincter, most often in spayed female dogs. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerProin (phenylpropanolamine) is a prescription medicine for dogs. It tightens the muscle that holds urine in. The most common side effects: restlessness, irritability, vomiting, more thirst and higher blood pressure.

Key facts

Generic namePhenylpropanolamine
Common brand namesProin
Used inDogs
TypeUrinary & kidney
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

Treats urinary incontinence from a weak urethral sphincter, most often in spayed female dogs. [1]

How it works

It tightens the muscle that holds urine in. [1]

Side effects and cautions

Common side effects: Restlessness, irritability, vomiting, more thirst and higher blood pressure. [1]

Use with care: Use caution with glaucoma, heart disease, high blood pressure or kidney disease. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Proin FAQ

What is Proin used for in dogs?

Treats urinary incontinence from a weak urethral sphincter, most often in spayed female dogs.

What are the side effects of Proin?

Restlessness, irritability, vomiting, more thirst and higher blood pressure.

Does Proin need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Proin should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

Related medications

Related cost guides

This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Phenylpropanolamine (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs