Heart & blood pressure Dogs & Cats

Spironolactone for dogs and cats

An add-on diuretic for heart failure and fluid buildup. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerSpironolactone is a prescription medicine for dogs and cats. It blocks aldosterone, which helps the body shed fluid while keeping potassium. The most common side effects: more drinking and urination, mild energy loss, vomiting and diarrhea.

Key facts

Generic nameSpironolactone
Common brand namesAldactone, Prilactone
Used inDogs & Cats
TypeHeart & blood pressure
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

An add-on diuretic for heart failure and fluid buildup. [1]

How it works

It blocks aldosterone, which helps the body shed fluid while keeping potassium. [1]

Side effects and cautions

Common side effects: More drinking and urination, mild energy loss, vomiting and diarrhea. Some cats get facial skin sores. [1]

Use with care: Not for pets with high potassium, Addison's disease or serious kidney problems. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Spironolactone FAQ

What is Spironolactone used for in dogs and cats?

An add-on diuretic for heart failure and fluid buildup.

What are the side effects of Spironolactone?

More drinking and urination, mild energy loss, vomiting and diarrhea. Some cats get facial skin sores.

Does Spironolactone need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Spironolactone should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

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This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Spironolactone (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs