Proin vs Incurin: what's the difference?
How Proin and Incurin compare: what each is for, how it works, side effects and cost, side by side.
Last updated: October 2026 · 2 sources · see sources
Side by side
| Proin | Incurin | |
|---|---|---|
| Generic name | Phenylpropanolamine | Estriol |
| Brand names | Proin | Incurin |
| For | Dogs | Dogs |
| Prescription | Prescription | Prescription |
| Used for | Treats urinary incontinence from a weak urethral sphincter, most often in spayed female dogs. [1] | Treats urinary incontinence in spayed female dogs. [2] |
| How it works | It tightens the muscle that holds urine in. [1] | A natural estrogen that helps the urethra muscle stay closed. [2] |
| Common side effects | Restlessness, irritability, vomiting, more thirst and higher blood pressure. [1] | Uncommon at the lowest effective dose: low appetite, vomiting, more thirst or a swollen vulva. [2] |
| Use with care | Use caution with glaucoma, heart disease, high blood pressure or kidney disease. [1] | Not for pregnant dogs or with other estrogen drugs. [2] |
| Full guide | Proin guide | Incurin guide |
Key differences
On the basics they are alike: same kind of animal, same way to get them. The differences are in how they work and what else they cover, shown in the table above.
Which one is right for my pet?
That is a call for your vet. They weigh your pet's age, weight, other health problems, other medicines and what you can realistically give at home.
Switching from Proin to Incurin is common, but do it only with your vet's plan.
Common questions
What is the difference between Proin and Incurin?
Both treat urinary leaking in spayed female dogs. Proin tightens the sphincter muscle; Incurin is an estrogen.
Is Proin better than Incurin?
Neither is better for every pet. Your vet chooses based on your pet's species, age, health history, other medicines and what you can manage at home.
Can my pet take Proin and Incurin together?
Only if your vet says so. Some medicines in the same family should not be combined, and others are often used together. Always check before adding or switching.
Do Proin and Incurin need a prescription?
Proin: Yes. It needs a prescription from a veterinarian. Incurin: Yes. It needs a prescription from a veterinarian.
Related
This page is general information for planning, not veterinary advice. Talk to your vet about your own pet.