Carprofen vs Deracoxib: what's the difference?
How Carprofen and Deracoxib compare: what each is for, how it works, side effects and cost, side by side.
Last updated: October 2026 · 4 sources · see sources
Side by side
| Carprofen | Deracoxib | |
|---|---|---|
| Generic name | Carprofen | Deracoxib |
| Brand names | Rimadyl, Novox, Vetprofen, Carprieve, Rovera | Deramaxx |
| For | Dogs | Dogs |
| Prescription | Prescription | Prescription |
| Used for | Treats pain and inflammation in dogs, such as arthritis pain and pain after surgery. [1] | Controls pain after surgery, such as orthopedic and dental surgery, and treats arthritis pain in dogs. [2] |
| How it works | It is an NSAID. It blocks enzymes that make prostaglandins, the chemicals that cause pain and swelling. [1] | A COX-2 selective NSAID that reduces the prostaglandins behind pain and inflammation. [2] |
| Common side effects | Vomiting, low appetite, diarrhea, constipation and tiredness. Rarely, liver, kidney or stomach damage. [1] | Diarrhea is most common, then vomiting, low appetite and weight loss. [2] |
| Use with care | Never combine with other NSAIDs or steroids. Not for dogs with bleeding disorders. Stop and call your vet for black or bloody stool, yellow gums or eyes, or changes in drinking or urination. Never give human pain relievers instead. [1] | Not for dogs allergic to sulfa drugs or other NSAIDs, or dogs with bloody stool or vomit. Don't combine with other NSAIDs or steroids. [2] |
| Typical price | Carprofen or Rimadyl: $12–$50 a month [3] Rimadyl, typical owner bill (103 bills): $15–$50 [4] | No reliable published price |
| Full guide | Carprofen (Rimadyl) guide | Deracoxib (Deramaxx) guide |
Key differences
On the basics they are alike: same kind of animal, same way to get them. The differences are in how they work and what else they cover, shown in the table above.
Which one is right for my pet?
That is a call for your vet. They weigh your pet's age, weight, other health problems, other medicines and what you can realistically give at home.
Switching from Carprofen to Deracoxib is common, but do it only with your vet's plan.
Common questions
What is the difference between Carprofen and Deracoxib?
Both are NSAIDs for dogs. Deracoxib is COX-2 selective and is labeled for pain after surgery as well as arthritis.
Is Carprofen better than Deracoxib?
Neither is better for every pet. Your vet chooses based on your pet's species, age, health history, other medicines and what you can manage at home.
Can my pet take Carprofen and Deracoxib together?
Only if your vet says so. Some medicines in the same family should not be combined, and others are often used together. Always check before adding or switching.
Do Carprofen and Deracoxib need a prescription?
Carprofen: Yes. It needs a prescription from a veterinarian. Deracoxib: Yes. It needs a prescription from a veterinarian.
How much do Carprofen and Deracoxib cost?
Carprofen: Carprofen or Rimadyl $12–$50 a month. Deracoxib: no reliable published price. Prices vary by pet size, pharmacy and clinic.
Related
This page is general information for planning, not veterinary advice. Talk to your vet about your own pet.