Simparica vs Credelio: what's the difference?
How Simparica and Credelio compare: what each is for, how it works, side effects and cost, side by side.
Last updated: October 2026 · 2 sources · see sources
Side by side
| Simparica | Credelio | |
|---|---|---|
| Generic name | Sarolaner | Lotilaner |
| Brand names | Simparica, Simparica Trio, Revolution Plus | Credelio, Credelio Cat, Credelio Quattro |
| For | Dogs and cats | Dogs and cats |
| Prescription | Prescription | Prescription |
| Used for | Kills fleas and ticks in dogs. Combined products also cover heartworm and worms, and Revolution Plus is made for cats. [1] | Kills fleas and treats and controls several kinds of ticks in dogs and cats. [2] |
| How it works | Absorbed into the body; fleas and ticks are killed when they feed. [1] | Absorbed into the body; fleas and ticks die after biting. [2] |
| Common side effects | Vomiting, diarrhea and low appetite. [1] | Vomiting, diarrhea, low appetite and flaky skin. [2] |
| Use with care | The single-drug Simparica chew is not for cats. An isoxazoline, so use caution in pets with seizures. [1] | An isoxazoline, so use caution in pets with seizures. Not for kittens under 8 weeks. [2] |
| Full guide | Simparica guide | Credelio guide |
Key differences
On the basics they are alike: same kind of animal, same way to get them. The differences are in how they work and what else they cover, shown in the table above.
Which one is right for my pet?
That is a call for your vet. They weigh your pet's age, weight, other health problems, other medicines and what you can realistically give at home.
Switching from Simparica to Credelio is common, but do it only with your vet's plan.
Common questions
What is the difference between Simparica and Credelio?
Both are flea and tick medicines absorbed into the body. Simparica's combination products also cover heartworm and worms.
Is Simparica better than Credelio?
Neither is better for every pet. Your vet chooses based on your pet's species, age, health history, other medicines and what you can manage at home.
Can my pet take Simparica and Credelio together?
Only if your vet says so. Some medicines in the same family should not be combined, and others are often used together. Always check before adding or switching.
Do Simparica and Credelio need a prescription?
Simparica: Yes. It needs a prescription from a veterinarian. Credelio: Yes. It needs a prescription from a veterinarian.
Related
This page is general information for planning, not veterinary advice. Talk to your vet about your own pet.