Cephalexin vs Clavamox: what's the difference?
How Cephalexin and Clavamox compare: what each is for, how it works, side effects and cost, side by side.
Last updated: October 2026 · 2 sources · see sources
Side by side
| Cephalexin | Clavamox | |
|---|---|---|
| Generic name | Cephalexin | Amoxicillin-clavulanate |
| Brand names | Rilexine, Keflex | Clavamox |
| For | Dogs and cats | Dogs and cats |
| Prescription | Prescription | Prescription |
| Used for | Treats skin infections (pyoderma) in dogs. Vets also use it in cats and for some urinary infections. [1] | Treats skin and soft tissue infections, gum disease in dogs and urinary infections in cats. [2] |
| How it works | A cephalosporin antibiotic that damages bacterial cell walls. [1] | Amoxicillin kills bacteria by damaging their cell walls. Clavulanate protects the amoxicillin from enzymes some bacteria use to fight back. [2] |
| Common side effects | Vomiting, diarrhea and low appetite. [1] | Stomach upset, vomiting and diarrhea. Giving it with food can help. [2] |
| Use with care | Not for pets allergic to cephalosporins; use caution with penicillin allergy. [1] | Not for pets allergic to penicillins or cephalosporins. Finish the full course even if your pet seems better. [2] |
| Full guide | Cephalexin guide | Clavamox guide |
Key differences
On the basics they are alike: same kind of animal, same way to get them. The differences are in how they work and what else they cover, shown in the table above.
Which one is right for my pet?
That is a call for your vet. They weigh your pet's age, weight, other health problems, other medicines and what you can realistically give at home.
Switching from Cephalexin to Clavamox is common, but do it only with your vet's plan.
Common questions
What is the difference between Cephalexin and Clavamox?
Both are common antibiotics for skin infections. Cephalexin is a cephalosporin; Clavamox is a protected penicillin.
Is Cephalexin better than Clavamox?
Neither is better for every pet. Your vet chooses based on your pet's species, age, health history, other medicines and what you can manage at home.
Can my pet take Cephalexin and Clavamox together?
Only if your vet says so. Some medicines in the same family should not be combined, and others are often used together. Always check before adding or switching.
Do Cephalexin and Clavamox need a prescription?
Cephalexin: Yes. It needs a prescription from a veterinarian. Clavamox: Yes. It needs a prescription from a veterinarian.
Related
This page is general information for planning, not veterinary advice. Talk to your vet about your own pet.