Pain & arthritis Dogs & Cats

Buprenorphine for dogs and cats

An opioid pain reliever used in the clinic and sometimes at home, especially in cats. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerBuprenorphine is a prescription medicine for dogs and cats. It partly activates opioid receptors, giving pain relief with a lower risk of slowed breathing than stronger opioids. The most common side effects: sleepiness is most common.

Key facts

Generic nameBuprenorphine
Common brand namesBuprenex, Simbadol
Used inDogs & Cats
TypePain & arthritis
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

An opioid pain reliever used in the clinic and sometimes at home, especially in cats. [1]

How it works

It partly activates opioid receptors, giving pain relief with a lower risk of slowed breathing than stronger opioids. [1]

Side effects and cautions

Common side effects: Sleepiness is most common. Serious slowing of breathing is uncommon. [1]

Use with care: A controlled substance. Not for pets on amitraz products such as certain tick collars. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Buprenorphine FAQ

What is Buprenorphine used for in dogs and cats?

An opioid pain reliever used in the clinic and sometimes at home, especially in cats.

What are the side effects of Buprenorphine?

Sleepiness is most common. Serious slowing of breathing is uncommon.

Does Buprenorphine need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Buprenorphine should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

Related medications

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This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Buprenorphine (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs