Antibiotics Dogs

Cefpodoxime (Simplicef) for dogs

Treats skin infections in dogs, and is sometimes used for urinary and respiratory infections. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerCefpodoxime is a prescription medicine for dogs. A once-a-day cephalosporin antibiotic. The most common side effects: vomiting, low appetite, diarrhea and tiredness.

Key facts

Generic nameCefpodoxime
Common brand namesSimplicef
Used inDogs
TypeAntibiotics
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

Treats skin infections in dogs, and is sometimes used for urinary and respiratory infections. [1]

How it works

A once-a-day cephalosporin antibiotic. [1]

Side effects and cautions

Common side effects: Vomiting, low appetite, diarrhea and tiredness. [1]

Use with care: Not for pets allergic to cephalosporins or penicillins. Use caution with kidney disease. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Cefpodoxime FAQ

What is Cefpodoxime used for in dogs?

Treats skin infections in dogs, and is sometimes used for urinary and respiratory infections.

What are the side effects of Cefpodoxime?

Vomiting, low appetite, diarrhea and tiredness.

Does Cefpodoxime need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Cefpodoxime should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

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This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Cefpodoxime (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs