Thyroid & hormones Dogs

Mitotane for dogs

An older treatment for Cushing's disease and adrenal tumors in dogs. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerMitotane is a prescription medicine for dogs. It destroys part of the adrenal gland tissue that makes cortisol. The most common side effects: vomiting and diarrhea.

Key facts

Generic nameMitotane
Common brand namesLysodren
Used inDogs
TypeThyroid & hormones
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

An older treatment for Cushing's disease and adrenal tumors in dogs. [1]

How it works

It destroys part of the adrenal gland tissue that makes cortisol. [1]

Side effects and cautions

Common side effects: Vomiting and diarrhea. Low appetite, weakness or wobbliness can mean cortisol has dropped too low. [1]

Use with care: Needs close vet monitoring. Wear gloves when handling. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Mitotane FAQ

What is Mitotane used for in dogs?

An older treatment for Cushing's disease and adrenal tumors in dogs.

What are the side effects of Mitotane?

Vomiting and diarrhea. Low appetite, weakness or wobbliness can mean cortisol has dropped too low.

Does Mitotane need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Mitotane should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

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This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Mitotane (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs