Thyroid & hormones Dogs

Zycortal / Percorten-V (DOCP) for dogs

An injection for Addison's disease (hypoadrenocorticism) in dogs. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerZycortal / Percorten-V (desoxycorticosterone pivalate) is a prescription, given at the clinic medicine for dogs. It replaces aldosterone, the hormone that balances sodium and potassium. Most dogs also need a daily steroid. The most common side effects: injection-site irritation.

Key facts

Generic nameDesoxycorticosterone pivalate
Common brand namesPercorten-V, Zycortal
Used inDogs
TypeThyroid & hormones
Prescription?Prescription, given at the clinic
Typical US priceNot listed (no reliable public source)

What it's used for

An injection for Addison's disease (hypoadrenocorticism) in dogs. [1]

How it works

It replaces aldosterone, the hormone that balances sodium and potassium. Most dogs also need a daily steroid. [1]

Side effects and cautions

Common side effects: Injection-site irritation. Increased thirst and urination or weakness can mean the dose needs adjusting. [1]

Use with care: Not for dogs with heart failure, advanced kidney disease or swelling. Regular electrolyte checks are needed. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Zycortal / Percorten-V FAQ

What is Zycortal / Percorten-V used for in dogs?

An injection for Addison's disease (hypoadrenocorticism) in dogs.

What are the side effects of Zycortal / Percorten-V?

Injection-site irritation. Increased thirst and urination or weakness can mean the dose needs adjusting.

Does Zycortal / Percorten-V need a prescription?

Yes. It's prescription-only and is usually given at the vet clinic.

How much Zycortal / Percorten-V should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

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This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Desoxycorticosterone pivalate (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs