Diabetes Dogs & Cats

NPH insulin (Humulin N, Novolin N) for dogs and cats

An intermediate-acting human insulin used mostly in diabetic dogs. [1]

Last reviewed: October 2026 · 4 sources · see sources

Quick answerNPH insulin (Humulin N, Novolin N) (nPH insulin) is a prescription medicine for dogs and cats. Protamine is added so it acts longer than regular insulin. The most common side effects: skin lumps; low blood sugar is the main risk.

Key facts

Generic nameNPH insulin
Common brand namesHumulin N, Novolin N
Used inDogs & Cats
TypeDiabetes
Prescription?Prescription
Typical US price$30–$150 a month [2]

What it's used for

An intermediate-acting human insulin used mostly in diabetic dogs. [1]

How it works

Protamine is added so it acts longer than regular insulin. [1]

Side effects and cautions

Common side effects: Skin lumps; low blood sugar is the main risk. [1]

Use with care: Use only the syringe type your vet prescribes (U-100). Signs of low blood sugar need urgent care. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [4].

What it costs

Prices come from public owner-bill reports and vary by clinic, pharmacy, pet size and dose.

NPH insulin (Humulin N, Novolin N) FAQ

What is NPH insulin (Humulin N, Novolin N) used for in dogs and cats?

An intermediate-acting human insulin used mostly in diabetic dogs.

What are the side effects of NPH insulin (Humulin N, Novolin N)?

Skin lumps; low blood sugar is the main risk.

Does NPH insulin (Humulin N, Novolin N) need a prescription?

Yes. It needs a prescription from a veterinarian.

How much NPH insulin (Humulin N, Novolin N) should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

Related medications

Related cost guides

This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (4) — tap to show
  1. VCA Animal Hospitals – NPH insulin (veterinary drug handout)
  2. PetRules USA – Cost of managing diabetes in dogs and cats
  3. RealVetCost – Feline diabetes treatment cost
  4. FDA – Frequently asked questions about animal drugs