Diabetes Dogs & Cats

ProZinc (PZI insulin) for dogs and cats

An injectable insulin approved for diabetic cats and dogs. [1]

Last reviewed: October 2026 · 4 sources · see sources

Quick answerProZinc (PZI insulin) (protamine zinc insulin) is a prescription medicine for dogs and cats. It replaces insulin so the body can move sugar out of the blood. The added protamine and zinc make it last longer. The most common side effects: lumps at injection sites.

Key facts

Generic nameProtamine zinc insulin
Common brand namesProZinc
Used inDogs & Cats
TypeDiabetes
Prescription?Prescription
Typical US price$30–$150 a month [2]

What it's used for

An injectable insulin approved for diabetic cats and dogs. [1]

How it works

It replaces insulin so the body can move sugar out of the blood. The added protamine and zinc make it last longer. [1]

Side effects and cautions

Common side effects: Lumps at injection sites. The main risk is low blood sugar. [1]

Use with care: Signs of low blood sugar include weakness, wobbliness, trembling and seizures; call your vet right away. Don't inject if your pet isn't eating unless your vet says to. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [4].

What it costs

Prices come from public owner-bill reports and vary by clinic, pharmacy, pet size and dose.

ProZinc (PZI insulin) FAQ

What is ProZinc (PZI insulin) used for in dogs and cats?

An injectable insulin approved for diabetic cats and dogs.

What are the side effects of ProZinc (PZI insulin)?

Lumps at injection sites. The main risk is low blood sugar.

Does ProZinc (PZI insulin) need a prescription?

Yes. It needs a prescription from a veterinarian.

How much ProZinc (PZI insulin) should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

Related medications

Related cost guides

This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (4) — tap to show
  1. VCA Animal Hospitals – Protamine zinc insulin (veterinary drug handout)
  2. PetRules USA – Cost of managing diabetes in dogs and cats
  3. RealVetCost – Feline diabetes treatment cost
  4. FDA – Frequently asked questions about animal drugs