Flea, tick & heartworm Dogs & Cats

Revolution for dogs and cats

A monthly topical that prevents heartworm and treats fleas, ear mites and some other parasites in dogs and cats (and worms in cats). [1]

Last reviewed: October 2026 · 3 sources · see sources

Quick answerRevolution (selamectin) is a prescription medicine for dogs and cats. It paralyzes and kills parasites by acting on their nerve and muscle cells. The most common side effects: rare.

Key facts

Generic nameSelamectin
Common brand namesRevolution, Stronghold
Used inDogs & Cats
TypeFlea, tick & heartworm
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

A monthly topical that prevents heartworm and treats fleas, ear mites and some other parasites in dogs and cats (and worms in cats). [1]

How it works

It paralyzes and kills parasites by acting on their nerve and muscle cells. [1]

Side effects and cautions

Common side effects: Rare. Hair loss at the application spot in cats, vomiting, diarrhea, itching or drooling. [1]

Use with care: Pets should be heartworm tested before starting. Use caution in dog breeds with the MDR1 gene change, such as collies. [1] [2]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [3].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Revolution FAQ

What is Revolution used for in dogs and cats?

A monthly topical that prevents heartworm and treats fleas, ear mites and some other parasites in dogs and cats (and worms in cats).

What are the side effects of Revolution?

Rare. Hair loss at the application spot in cats, vomiting, diarrhea, itching or drooling.

Does Revolution need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Revolution should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

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This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (3) — tap to show
  1. VCA Animal Hospitals – Selamectin (veterinary drug handout)
  2. FDA – Keep worms out of your pet's heart
  3. FDA – Frequently asked questions about animal drugs