Revolution vs Advantage: what's the difference?
How Revolution and Advantage compare: what each is for, how it works, side effects and cost, side by side.
Last updated: October 2026 · 2 sources · see sources
Side by side
| Revolution | Advantage | |
|---|---|---|
| Generic name | Selamectin | Imidacloprid |
| Brand names | Revolution, Stronghold | Advantage, Advantage II, Advantage Multi, K9 Advantix, Seresto |
| For | Dogs and cats | Dogs and cats |
| Prescription | Prescription | Over the counter (ask your vet first) |
| Used for | A monthly topical that prevents heartworm and treats fleas, ear mites and some other parasites in dogs and cats (and worms in cats). [1] | Kills fleas. Combination products also cover ticks, mosquitoes, lice, heartworm and some worms. [2] |
| How it works | It paralyzes and kills parasites by acting on their nerve and muscle cells. [1] | It attacks the flea's nervous system on contact. [2] |
| Common side effects | Rare. Hair loss at the application spot in cats, vomiting, diarrhea, itching or drooling. [1] | Skin irritation where it was applied; drooling if a pet licks it. [2] |
| Use with care | Pets should be heartworm tested before starting. Use caution in dog breeds with the MDR1 gene change, such as collies. [1] | Some combination products made for dogs must never be used on cats. Use only the product and size meant for your pet. [2] |
| Full guide | Revolution guide | Advantage guide |
Key differences
- How you get them differs: Revolution is prescription; Advantage is over the counter.
Which one is right for my pet?
That is a call for your vet. They weigh your pet's age, weight, other health problems, other medicines and what you can realistically give at home.
Switching from Revolution to Advantage is common, but do it only with your vet's plan.
Common questions
What is the difference between Revolution and Advantage?
Revolution is a prescription monthly topical that also prevents heartworm and treats ear mites; Advantage kills fleas on contact and is sold without a prescription.
Is Revolution better than Advantage?
Neither is better for every pet. Your vet chooses based on your pet's species, age, health history, other medicines and what you can manage at home.
Can my pet take Revolution and Advantage together?
Only if your vet says so. Some medicines in the same family should not be combined, and others are often used together. Always check before adding or switching.
Do Revolution and Advantage need a prescription?
Revolution: Yes. It needs a prescription from a veterinarian. Advantage: Many forms are sold without a prescription. Still, check with your vet first. Pet doses and safe products are not the same as for people.
Related
This page is general information for planning, not veterinary advice. Talk to your vet about your own pet.