Senvelgo vs ProZinc: what's the difference?
How Senvelgo and ProZinc compare: what each is for, how it works, side effects and cost, side by side.
Last updated: October 2026 · 4 sources · see sources
Side by side
| Senvelgo | ProZinc | |
|---|---|---|
| Generic name | Velagliflozin | Protamine zinc insulin |
| Brand names | Senvelgo | ProZinc |
| For | Cats | Dogs and cats |
| Prescription | Prescription | Prescription |
| Used for | A daily liquid for newly diagnosed diabetic cats that have not been treated with insulin. [1] | An injectable insulin approved for diabetic cats and dogs. [2] |
| How it works | An SGLT2 inhibitor: it helps the kidneys remove extra sugar through the urine. [1] | It replaces insulin so the body can move sugar out of the blood. The added protamine and zinc make it last longer. [2] |
| Common side effects | Weight loss, vomiting, diarrhea, more thirst and urination, drooling and dehydration. [1] | Lumps at injection sites. The main risk is low blood sugar. [2] |
| Use with care | Not for cats previously treated with insulin. Watch for signs of ketoacidosis such as not eating, weakness or vomiting. [1] | Signs of low blood sugar include weakness, wobbliness, trembling and seizures; call your vet right away. Don't inject if your pet isn't eating unless your vet says to. [2] |
| Typical price | No reliable published price | Insulin for a dog (any type): $30–$150 a month [3] Insulin for a cat (any type): $50–$150 a month [4] |
| Full guide | Senvelgo guide | ProZinc (PZI insulin) guide |
Key differences
- They aren't made for the same animals: Senvelgo is for cats; ProZinc is for dogs and cats.
Which one is right for my pet?
That is a call for your vet. They weigh your pet's age, weight, other health problems, other medicines and what you can realistically give at home.
Switching from Senvelgo to ProZinc is common, but do it only with your vet's plan.
Common questions
What is the difference between Senvelgo and ProZinc?
Senvelgo is a daily liquid for certain newly diagnosed cats; insulin is a shot. Your vet decides which cats are good candidates.
Is Senvelgo better than ProZinc?
Neither is better for every pet. Your vet chooses based on your pet's species, age, health history, other medicines and what you can manage at home.
Can my pet take Senvelgo and ProZinc together?
Only if your vet says so. Some medicines in the same family should not be combined, and others are often used together. Always check before adding or switching.
Do Senvelgo and ProZinc need a prescription?
Senvelgo: Yes. It needs a prescription from a veterinarian. ProZinc: Yes. It needs a prescription from a veterinarian.
How much do Senvelgo and ProZinc cost?
Senvelgo: no reliable published price. ProZinc: Insulin for a dog (any type) $30–$150 a month. Prices vary by pet size, pharmacy and clinic.
Related
This page is general information for planning, not veterinary advice. Talk to your vet about your own pet.