Ivermectin vs Revolution: what's the difference?
How Ivermectin and Revolution compare: what each is for, how it works, side effects and cost, side by side.
Last updated: October 2026 · 3 sources · see sources
Side by side
| Ivermectin | Revolution | |
|---|---|---|
| Generic name | Ivermectin | Selamectin |
| Brand names | Heartgard, Heartgard Plus, Tri-Heart | Revolution, Stronghold |
| For | Dogs and cats | Dogs and cats |
| Prescription | Prescription | Prescription |
| Used for | Mainly a monthly heartworm preventive. Vets also use it for mites and some worms. [1] | A monthly topical that prevents heartworm and treats fleas, ear mites and some other parasites in dogs and cats (and worms in cats). [2] |
| How it works | At preventive doses it kills young heartworm larvae before they can grow into adult worms. [1] | It paralyzes and kills parasites by acting on their nerve and muscle cells. [2] |
| Common side effects | Well tolerated at heartworm-prevention doses. Higher doses can cause wobbliness, tremors, dilated pupils and drooling. [1] | Rare. Hair loss at the application spot in cats, vomiting, diarrhea, itching or drooling. [2] |
| Use with care | Collies, sheepdogs and related breeds can be very sensitive at high doses (MDR1 gene). Dogs need a negative heartworm test first. [1] | Pets should be heartworm tested before starting. Use caution in dog breeds with the MDR1 gene change, such as collies. [2] |
| Typical price | Monthly heartworm preventive, as listed on owner bills: $6–$18 a dose [3] | No reliable published price |
| Full guide | Ivermectin (Heartgard) guide | Revolution guide |
Key differences
On the basics they are alike: same kind of animal, same way to get them. The differences are in how they work and what else they cover, shown in the table above.
Which one is right for my pet?
That is a call for your vet. They weigh your pet's age, weight, other health problems, other medicines and what you can realistically give at home.
Switching from Ivermectin to Revolution is common, but do it only with your vet's plan.
Common questions
What is the difference between Ivermectin and Revolution?
Both prevent heartworm. Heartgard is given by mouth; Revolution is a topical that also treats fleas and ear mites.
Is Ivermectin better than Revolution?
Neither is better for every pet. Your vet chooses based on your pet's species, age, health history, other medicines and what you can manage at home.
Can my pet take Ivermectin and Revolution together?
Only if your vet says so. Some medicines in the same family should not be combined, and others are often used together. Always check before adding or switching.
Do Ivermectin and Revolution need a prescription?
Ivermectin: Yes. It needs a prescription from a veterinarian. Revolution: Yes. It needs a prescription from a veterinarian.
How much do Ivermectin and Revolution cost?
Ivermectin: Monthly heartworm preventive, as listed on owner bills $6–$18 a dose. Revolution: no reliable published price. Prices vary by pet size, pharmacy and clinic.
Related
This page is general information for planning, not veterinary advice. Talk to your vet about your own pet.