Flea, tick & heartworm Dogs & Cats

Advantage for dogs and cats

Kills fleas. Combination products also cover ticks, mosquitoes, lice, heartworm and some worms. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerAdvantage (imidacloprid) is a over the counter medicine for dogs and cats. It attacks the flea's nervous system on contact. The most common side effects: skin irritation where it was applied; drooling if a pet licks it.

Key facts

Generic nameImidacloprid
Common brand namesAdvantage, Advantage II, Advantage Multi, K9 Advantix, Seresto
Used inDogs & Cats
TypeFlea, tick & heartworm
Prescription?Over the counter (ask your vet first)
Typical US priceNot listed (no reliable public source)

What it's used for

Kills fleas. Combination products also cover ticks, mosquitoes, lice, heartworm and some worms. [1]

How it works

It attacks the flea's nervous system on contact. [1]

Side effects and cautions

Common side effects: Skin irritation where it was applied; drooling if a pet licks it. [1]

Use with care: Some combination products made for dogs must never be used on cats. Use only the product and size meant for your pet. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Advantage FAQ

What is Advantage used for in dogs and cats?

Kills fleas. Combination products also cover ticks, mosquitoes, lice, heartworm and some worms.

What are the side effects of Advantage?

Skin irritation where it was applied; drooling if a pet licks it.

Does Advantage need a prescription?

Many forms are sold without a prescription. Still, check with your vet first. Pet doses and safe products are not the same as for people.

How much Advantage should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

Related medications

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This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Imidacloprid (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs