Allergy & itch Dogs & Cats

Benadryl for dogs and cats

Used for allergic reactions, motion sickness and vomiting, and as a mild sedative. It is also part of treatment for mast cell tumors. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerBenadryl (diphenhydramine) is a over the counter medicine for dogs and cats. It is an older antihistamine that blocks histamine and also causes drowsiness. The most common side effects: tiredness, excitement (especially in cats), dry mouth, trouble urinating, vomiting, diarrhea and low appetite.

Key facts

Generic nameDiphenhydramine
Common brand namesBenadryl, Vetadryl
Used inDogs & Cats
TypeAllergy & itch
Prescription?Over the counter (ask your vet first)
Typical US priceNot listed (no reliable public source)

What it's used for

Used for allergic reactions, motion sickness and vomiting, and as a mild sedative. It is also part of treatment for mast cell tumors. [1]

How it works

It is an older antihistamine that blocks histamine and also causes drowsiness. [1]

Side effects and cautions

Common side effects: Tiredness, excitement (especially in cats), dry mouth, trouble urinating, vomiting, diarrhea and low appetite. [1]

Use with care: Use caution in pets with glaucoma, prostate enlargement, heart disease or high blood pressure. Many human products add other drugs that pets should not have, so check with your vet first. Stop it two weeks before skin allergy testing. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Benadryl FAQ

What is Benadryl used for in dogs and cats?

Used for allergic reactions, motion sickness and vomiting, and as a mild sedative. It is also part of treatment for mast cell tumors.

What are the side effects of Benadryl?

Tiredness, excitement (especially in cats), dry mouth, trouble urinating, vomiting, diarrhea and low appetite.

Does Benadryl need a prescription?

Many forms are sold without a prescription. Still, check with your vet first. Pet doses and safe products are not the same as for people.

How much Benadryl should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

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This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Diphenhydramine (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs