Allergy & itch Dogs & Cats

Chlorpheniramine for dogs and cats

An antihistamine for allergic conditions, sometimes used as a mild sedative. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerChlorpheniramine (chlorpheniramine maleate) is a over the counter medicine for dogs and cats. It blocks histamine to reduce itching and other allergy signs. The most common side effects: sleepiness, excitement in cats, diarrhea, vomiting, lower appetite, dry mouth and mild straining to urinate.

Key facts

Generic nameChlorpheniramine maleate
Common brand namesChlor-Trimeton, Aller-Chlor
Used inDogs & Cats
TypeAllergy & itch
Prescription?Over the counter (ask your vet first)
Typical US priceNot listed (no reliable public source)

What it's used for

An antihistamine for allergic conditions, sometimes used as a mild sedative. [1]

How it works

It blocks histamine to reduce itching and other allergy signs. [1]

Side effects and cautions

Common side effects: Sleepiness, excitement in cats, diarrhea, vomiting, lower appetite, dry mouth and mild straining to urinate. [1]

Use with care: Use caution in pets with glaucoma, an enlarged prostate, hyperthyroidism, or heart disease. Avoid combination cold products. Ask your vet first. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Chlorpheniramine FAQ

What is Chlorpheniramine used for in dogs and cats?

An antihistamine for allergic conditions, sometimes used as a mild sedative.

What are the side effects of Chlorpheniramine?

Sleepiness, excitement in cats, diarrhea, vomiting, lower appetite, dry mouth and mild straining to urinate.

Does Chlorpheniramine need a prescription?

Many forms are sold without a prescription. Still, check with your vet first. Pet doses and safe products are not the same as for people.

How much Chlorpheniramine should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

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This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Chlorpheniramine maleate (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs