Allergy & itch Dogs & Cats

Cyproheptadine for dogs and cats

An antihistamine for itchy and allergic skin. It is also used as an appetite stimulant in cats and for some poisonings. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerCyproheptadine is a prescription medicine for dogs and cats. It blocks histamine and serotonin, which explains both its allergy and appetite effects. The most common side effects: sleepiness, increased appetite, dry mouth, excitability in cats, vomiting and diarrhea.

Key facts

Generic nameCyproheptadine
Common brand namesPeriactin
Used inDogs & Cats
TypeAllergy & itch
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

An antihistamine for itchy and allergic skin. It is also used as an appetite stimulant in cats and for some poisonings. [1]

How it works

It blocks histamine and serotonin, which explains both its allergy and appetite effects. [1]

Side effects and cautions

Common side effects: Sleepiness, increased appetite, dry mouth, excitability in cats, vomiting and diarrhea. [1]

Use with care: Stop it two weeks before skin allergy testing. Use caution in older pets and pregnant or nursing pets. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Cyproheptadine FAQ

What is Cyproheptadine used for in dogs and cats?

An antihistamine for itchy and allergic skin. It is also used as an appetite stimulant in cats and for some poisonings.

What are the side effects of Cyproheptadine?

Sleepiness, increased appetite, dry mouth, excitability in cats, vomiting and diarrhea.

Does Cyproheptadine need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Cyproheptadine should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

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This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Cyproheptadine (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs