Flea, tick & heartworm Dogs & Cats

Comfortis for dogs and cats

A monthly chewable that kills fleas in dogs and cats. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerComfortis (spinosad) is a prescription medicine for dogs and cats. It overstimulates the flea's nervous system. The most common side effects: vomiting, low appetite, diarrhea and drooling.

Key facts

Generic nameSpinosad
Common brand namesComfortis, Trifexis
Used inDogs & Cats
TypeFlea, tick & heartworm
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

A monthly chewable that kills fleas in dogs and cats. [1]

How it works

It overstimulates the flea's nervous system. [1]

Side effects and cautions

Common side effects: Vomiting, low appetite, diarrhea and drooling. [1]

Use with care: Use caution in pets with seizures and pets taking ivermectin at high doses. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Comfortis FAQ

What is Comfortis used for in dogs and cats?

A monthly chewable that kills fleas in dogs and cats.

What are the side effects of Comfortis?

Vomiting, low appetite, diarrhea and drooling.

Does Comfortis need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Comfortis should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

Related medications

Related cost guides

This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Spinosad (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs