Flea, tick & heartworm Dogs & Cats

Interceptor for dogs and cats

Prevents heartworm and treats hookworms and roundworms. Some combinations also control fleas. [1]

Last reviewed: October 2026 · 4 sources · see sources

Quick answerInterceptor (milbemycin oxime) is a prescription medicine for dogs and cats. It kills heartworm larvae and some intestinal worms by acting on their nerves. The most common side effects: well tolerated at regular doses.

Key facts

Generic nameMilbemycin oxime
Common brand namesInterceptor, Sentinel, Trifexis
Used inDogs & Cats
TypeFlea, tick & heartworm
Prescription?Prescription
Typical US price$6–$18 a dose [3]

What it's used for

Prevents heartworm and treats hookworms and roundworms. Some combinations also control fleas. [1]

How it works

It kills heartworm larvae and some intestinal worms by acting on their nerves. [1]

Side effects and cautions

Common side effects: Well tolerated at regular doses. Higher doses can cause weakness, wobbliness and drooling. [1]

Use with care: Dogs need a negative heartworm test before starting. [1] [2]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [4].

What it costs

Prices come from public owner-bill reports and vary by clinic, pharmacy, pet size and dose.

Interceptor FAQ

What is Interceptor used for in dogs and cats?

Prevents heartworm and treats hookworms and roundworms. Some combinations also control fleas.

What are the side effects of Interceptor?

Well tolerated at regular doses. Higher doses can cause weakness, wobbliness and drooling.

Does Interceptor need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Interceptor should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

Related medications

Related cost guides

This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (4) — tap to show
  1. VCA Animal Hospitals – Milbemycin oxime (veterinary drug handout)
  2. FDA – Keep worms out of your pet's heart
  3. VetReceipt – Dog heartworm treatment cost (owner bills)
  4. FDA – Frequently asked questions about animal drugs