Flea, tick & heartworm Dogs

NexGard for dogs

A monthly chew that kills fleas and ticks in dogs and helps prevent Lyme disease. [1]

Last reviewed: October 2026 · 3 sources · see sources

Quick answerNexGard (afoxolaner) is a prescription medicine for dogs. It spreads through the dog's body, and fleas and ticks die after biting. The most common side effects: very few in most dogs.

Key facts

Generic nameAfoxolaner
Common brand namesNexGard, NexGard Plus, NexGard Spectra
Used inDogs
TypeFlea, tick & heartworm
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

A monthly chew that kills fleas and ticks in dogs and helps prevent Lyme disease. [1]

How it works

It spreads through the dog's body, and fleas and ticks die after biting. [1]

Side effects and cautions

Common side effects: Very few in most dogs. Vomiting and diarrhea can happen. [1]

Use with care: An isoxazoline: the FDA has warned of possible tremors, wobbliness and seizures. Not for puppies under 8 weeks or 4 pounds unless your vet says so. [1] [2]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [3].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

NexGard FAQ

What is NexGard used for in dogs?

A monthly chew that kills fleas and ticks in dogs and helps prevent Lyme disease.

What are the side effects of NexGard?

Very few in most dogs. Vomiting and diarrhea can happen.

Does NexGard need a prescription?

Yes. It needs a prescription from a veterinarian.

How much NexGard should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

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This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (3) — tap to show
  1. VCA Animal Hospitals – Afoxolaner (veterinary drug handout)
  2. FDA – Fact sheet about isoxazoline flea and tick products
  3. FDA – Frequently asked questions about animal drugs