Flea, tick & heartworm Dogs & Cats

Simparica for dogs and cats

Kills fleas and ticks in dogs. Combined products also cover heartworm and worms, and Revolution Plus is made for cats. [1]

Last reviewed: October 2026 · 3 sources · see sources

Quick answerSimparica (sarolaner) is a prescription medicine for dogs and cats. Absorbed into the body; fleas and ticks are killed when they feed. The most common side effects: vomiting, diarrhea and low appetite.

Key facts

Generic nameSarolaner
Common brand namesSimparica, Simparica Trio, Revolution Plus
Used inDogs & Cats
TypeFlea, tick & heartworm
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

Kills fleas and ticks in dogs. Combined products also cover heartworm and worms, and Revolution Plus is made for cats. [1]

How it works

Absorbed into the body; fleas and ticks are killed when they feed. [1]

Side effects and cautions

Common side effects: Vomiting, diarrhea and low appetite. [1]

Use with care: The single-drug Simparica chew is not for cats. An isoxazoline, so use caution in pets with seizures. [1] [2]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [3].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Simparica FAQ

What is Simparica used for in dogs and cats?

Kills fleas and ticks in dogs. Combined products also cover heartworm and worms, and Revolution Plus is made for cats.

What are the side effects of Simparica?

Vomiting, diarrhea and low appetite.

Does Simparica need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Simparica should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

Related medications

Related cost guides

This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (3) — tap to show
  1. VCA Animal Hospitals – Sarolaner (veterinary drug handout)
  2. FDA – Fact sheet about isoxazoline flea and tick products
  3. FDA – Frequently asked questions about animal drugs