Revolution vs Frontline: what's the difference?
How Revolution and Frontline compare: what each is for, how it works, side effects and cost, side by side.
Last updated: October 2026 · 2 sources · see sources
Side by side
| Revolution | Frontline | |
|---|---|---|
| Generic name | Selamectin | Fipronil |
| Brand names | Revolution, Stronghold | Frontline, PetArmor, Parastar |
| For | Dogs and cats | Dogs and cats |
| Prescription | Prescription | Over the counter (ask your vet first) |
| Used for | A monthly topical that prevents heartworm and treats fleas, ear mites and some other parasites in dogs and cats (and worms in cats). [1] | A topical that kills fleas, ticks and chewing lice in dogs and cats. [2] |
| How it works | It paralyzes and kills parasites by acting on their nerve and muscle cells. [1] | It disrupts the nervous system of insects and ticks. [2] |
| Common side effects | Rare. Hair loss at the application spot in cats, vomiting, diarrhea, itching or drooling. [1] | Uncommon. Temporary irritation at the application spot. [2] |
| Use with care | Pets should be heartworm tested before starting. Use caution in dog breeds with the MDR1 gene change, such as collies. [1] | Not for puppies or kittens under 8 weeks, or for rabbits. Use the right product for your pet's species and weight. [2] |
| Full guide | Revolution guide | Frontline guide |
Key differences
- How you get them differs: Revolution is prescription; Frontline is over the counter.
Which one is right for my pet?
That is a call for your vet. They weigh your pet's age, weight, other health problems, other medicines and what you can realistically give at home.
Switching from Revolution to Frontline is common, but do it only with your vet's plan.
Common questions
What is the difference between Revolution and Frontline?
Revolution is a prescription topical that also prevents heartworm; Frontline is an over-the-counter topical for fleas, ticks and lice.
Is Revolution better than Frontline?
Neither is better for every pet. Your vet chooses based on your pet's species, age, health history, other medicines and what you can manage at home.
Can my pet take Revolution and Frontline together?
Only if your vet says so. Some medicines in the same family should not be combined, and others are often used together. Always check before adding or switching.
Do Revolution and Frontline need a prescription?
Revolution: Yes. It needs a prescription from a veterinarian. Frontline: Many forms are sold without a prescription. Still, check with your vet first. Pet doses and safe products are not the same as for people.
Related
This page is general information for planning, not veterinary advice. Talk to your vet about your own pet.