Allergy & itch Dogs

Apoquel for dogs

Controls itching from allergic skin disease, including atopic dermatitis, in dogs at least 12 months old. Vets occasionally use it for other skin problems. [1]

Last reviewed: October 2026 · 3 sources · see sources

Quick answerApoquel (oclacitinib) is a prescription medicine for dogs. It blocks JAK enzymes, which are part of the signal chain that drives itch and inflammation. Many dogs feel relief within a day or two. The most common side effects: vomiting, diarrhea or a lower appetite; tiredness; a higher chance of infections such as urinary, skin or respiratory infections; new skin lumps.

Key facts

Generic nameOclacitinib
Common brand namesApoquel
Used inDogs
TypeAllergy & itch
Prescription?Prescription
Typical US price$30–$90 [2]

What it's used for

Controls itching from allergic skin disease, including atopic dermatitis, in dogs at least 12 months old. Vets occasionally use it for other skin problems. [1]

How it works

It blocks JAK enzymes, which are part of the signal chain that drives itch and inflammation. Many dogs feel relief within a day or two. [1]

Side effects and cautions

Common side effects: Vomiting, diarrhea or a lower appetite; tiredness; a higher chance of infections such as urinary, skin or respiratory infections; new skin lumps. [1]

Use with care: Not for dogs with recent or current demodectic mange, serious infections, or cancer. Wear gloves or wash your hands after handling. Call your vet about fever, breathing trouble or any new lump. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [3].

What it costs

Prices come from public owner-bill reports and vary by clinic, pharmacy, pet size and dose.

Apoquel FAQ

What is Apoquel used for in dogs?

Controls itching from allergic skin disease, including atopic dermatitis, in dogs at least 12 months old. Vets occasionally use it for other skin problems.

What are the side effects of Apoquel?

Vomiting, diarrhea or a lower appetite; tiredness; a higher chance of infections such as urinary, skin or respiratory infections; new skin lumps.

Does Apoquel need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Apoquel should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

Related medications

Related cost guides

This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (3) — tap to show
  1. VCA Animal Hospitals – Oclacitinib (veterinary drug handout)
  2. VetReceipt – Dog skin allergy treatment cost (owner bills)
  3. FDA – Frequently asked questions about animal drugs