Anxiety & behavior Dogs & Cats

Fluoxetine (Prozac, Reconcile) for dogs and cats

Treats behavior problems; the FDA-approved dog form is labeled for separation anxiety. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerFluoxetine is a prescription medicine for dogs and cats. An SSRI: it raises serotonin over several weeks to lower anxiety. The most common side effects: sleepiness and low appetite are common; vomiting, diarrhea, shaking, restlessness and panting.

Key facts

Generic nameFluoxetine
Common brand namesReconcile, Prozac
Used inDogs & Cats
TypeAnxiety & behavior
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

Treats behavior problems; the FDA-approved dog form is labeled for separation anxiety. [1]

How it works

An SSRI: it raises serotonin over several weeks to lower anxiety. [1]

Side effects and cautions

Common side effects: Sleepiness and low appetite are common; vomiting, diarrhea, shaking, restlessness and panting. Cats may be irritable. [1]

Use with care: Not for pets with seizures or on MAOIs. It can take a few weeks to see the full effect. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Fluoxetine FAQ

What is Fluoxetine used for in dogs and cats?

Treats behavior problems; the FDA-approved dog form is labeled for separation anxiety.

What are the side effects of Fluoxetine?

Sleepiness and low appetite are common; vomiting, diarrhea, shaking, restlessness and panting. Cats may be irritable.

Does Fluoxetine need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Fluoxetine should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

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This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Fluoxetine (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs