Anxiety & behavior Dogs & Cats

Trazodone for dogs and cats

Eases anxiety and fear in dogs (separation anxiety, fireworks, vet visits, travel, crate rest) and is used before vet visits in cats. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerTrazodone is a prescription medicine for dogs and cats. It raises serotonin activity in the brain, which has a calming, sedating effect. The most common side effects: usually mild: sleepiness, dilated pupils, vomiting or wobbliness.

Key facts

Generic nameTrazodone
Common brand namesDesyrel
Used inDogs & Cats
TypeAnxiety & behavior
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

Eases anxiety and fear in dogs (separation anxiety, fireworks, vet visits, travel, crate rest) and is used before vet visits in cats. [1]

How it works

It raises serotonin activity in the brain, which has a calming, sedating effect. [1]

Side effects and cautions

Common side effects: Usually mild: sleepiness, dilated pupils, vomiting or wobbliness. Rarely more agitation. [1]

Use with care: Not with MAOIs such as selegiline or amitraz tick collars. Tell your vet about other serotonin drugs such as fluoxetine or tramadol. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Trazodone FAQ

What is Trazodone used for in dogs and cats?

Eases anxiety and fear in dogs (separation anxiety, fireworks, vet visits, travel, crate rest) and is used before vet visits in cats.

What are the side effects of Trazodone?

Usually mild: sleepiness, dilated pupils, vomiting or wobbliness. Rarely more agitation.

Does Trazodone need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Trazodone should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

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This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Trazodone (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs