Anxiety & behavior Dogs & Cats

Sileo (Dexmedetomidine) for dogs and cats

Sileo, a gel rubbed on the gums, eases noise aversion in dogs. The injection (Dexdomitor) is used for sedation at the clinic. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerSileo (dexmedetomidine) is a prescription medicine for dogs and cats. It lowers the release of norepinephrine, the body's alarm chemical. The most common side effects: brief heavy sedation, pale gums and slow heart and breathing rates.

Key facts

Generic nameDexmedetomidine
Common brand namesSileo, Dexdomitor
Used inDogs & Cats
TypeAnxiety & behavior
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

Sileo, a gel rubbed on the gums, eases noise aversion in dogs. The injection (Dexdomitor) is used for sedation at the clinic. [1]

How it works

It lowers the release of norepinephrine, the body's alarm chemical. [1]

Side effects and cautions

Common side effects: Brief heavy sedation, pale gums and slow heart and breathing rates. [1]

Use with care: Not for pets with severe heart, lung, liver or kidney disease. Wear gloves when applying the gel. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Sileo FAQ

What is Sileo used for in dogs and cats?

Sileo, a gel rubbed on the gums, eases noise aversion in dogs. The injection (Dexdomitor) is used for sedation at the clinic.

What are the side effects of Sileo?

Brief heavy sedation, pale gums and slow heart and breathing rates.

Does Sileo need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Sileo should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

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This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Dexmedetomidine (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs