Allergy & itch Dogs & Cats

Hydroxyzine for dogs and cats

An antihistamine for allergic and itchy skin, and sometimes as a sedative. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerHydroxyzine is a prescription medicine for dogs and cats. It blocks histamine and has a calming effect. The most common side effects: sleepiness, excitability, tremors, dry mouth, more drinking, constipation and low appetite.

Key facts

Generic nameHydroxyzine
Common brand namesAtarax, Vistaril
Used inDogs & Cats
TypeAllergy & itch
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

An antihistamine for allergic and itchy skin, and sometimes as a sedative. [1]

How it works

It blocks histamine and has a calming effect. [1]

Side effects and cautions

Common side effects: Sleepiness, excitability, tremors, dry mouth, more drinking, constipation and low appetite. [1]

Use with care: Not for pets with heart failure or urinary or stomach blockage, or pets allergic to cetirizine. Use extra care in pets with seizures. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Hydroxyzine FAQ

What is Hydroxyzine used for in dogs and cats?

An antihistamine for allergic and itchy skin, and sometimes as a sedative.

What are the side effects of Hydroxyzine?

Sleepiness, excitability, tremors, dry mouth, more drinking, constipation and low appetite.

Does Hydroxyzine need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Hydroxyzine should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

Related medications

Related cost guides

This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Hydroxyzine (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs