Anxiety & behavior Dogs & Cats

Clomipramine (Clomicalm) for dogs and cats

Treats separation anxiety and compulsive behaviors in dogs, and urine spraying and compulsive behavior in cats. [1]

Last reviewed: October 2026 · 2 sources · see sources

Quick answerClomipramine is a prescription medicine for dogs and cats. A tricyclic antidepressant that boosts serotonin and norepinephrine. The most common side effects: constipation, diarrhea, trouble urinating, dry mouth, low appetite, tiredness and vomiting.

Key facts

Generic nameClomipramine
Common brand namesClomicalm
Used inDogs & Cats
TypeAnxiety & behavior
Prescription?Prescription
Typical US priceNot listed (no reliable public source)

What it's used for

Treats separation anxiety and compulsive behaviors in dogs, and urine spraying and compulsive behavior in cats. [1]

How it works

A tricyclic antidepressant that boosts serotonin and norepinephrine. [1]

Side effects and cautions

Common side effects: Constipation, diarrhea, trouble urinating, dry mouth, low appetite, tiredness and vomiting. Cats are more sensitive. [1]

Use with care: Not with MAOIs (including amitraz collars) or in pets with seizures. [1]

Call your vet right away if your pet has trouble breathing, facial swelling, hives, collapse, or any side effect that is severe or getting worse.

About dosingDosing is your vet's call. We don't list doses because the right amount depends on your pet's weight, age, health and other medicines. Don't change a dose or stop a medicine without asking your vet, and never give a pet medicine meant for people unless your vet tells you to [2].

What it costs

We don't list a price for this one because we couldn't find a reliable public source. Ask your vet or pharmacy for a quote; prices depend on your pet's size, the dose and where you fill it.

Clomipramine FAQ

What is Clomipramine used for in dogs and cats?

Treats separation anxiety and compulsive behaviors in dogs, and urine spraying and compulsive behavior in cats.

What are the side effects of Clomipramine?

Constipation, diarrhea, trouble urinating, dry mouth, low appetite, tiredness and vomiting. Cats are more sensitive.

Does Clomipramine need a prescription?

Yes. It needs a prescription from a veterinarian.

How much Clomipramine should I give my pet?

Only your veterinarian can tell you. The right dose depends on your pet's weight, health and other medicines, so we don't list doses. Never give a pet a medicine prescribed for a person or another animal without asking your vet.

Related medications

Related cost guides

This page is general information for pet owners, not veterinary advice. Talk to your vet about your own pet.

Sources (2) — tap to show
  1. VCA Animal Hospitals – Clomipramine (veterinary drug handout)
  2. FDA – Frequently asked questions about animal drugs